Document 3077
 DOCN  M94A3077
 TI    Relations of trace element status to immunological activity markers and
       progression of human immunodeficiency virus infection.
 DT    9412
 AU    Dousset B; May T; Dubois F; Allavena C; Rabaud C; Nabet-Belleville F;
       Canton P; Department of Biochemistry and Infectious Diseases, CHU
       Nancy,; France.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):159 (abstract no. PB0063). Unique
       Identifier : AIDSLINE ICA10/94369498
 AB    OBJECTIVE: To analyze the relationships between blood trace elements and
       beta 2 microglobuline levels in the 2 years follow-up of HIV infected
       patients with respect to the clinical evolution. METHODS: The study
       group consisted of 148 patients (36 females and 112 males, age: 33 +/- 9
       years) at various stages of HIV infection. Subjects exhibited no severe
       renal disease or liver disease or hypoalbuminemia. 30 age cross-matched
       healthy volunteers subjects (11 females, 19 males) served as controls.
       Serum (zinc: Zn, selenium: Se, copper: Cu) levels, beta 2 microglobuline
       (B2M) concentrations and CD4 and CD8 counts were examined. RESULTS: In
       the HIV infected group, the decrease in Se and Zn levels as well as the
       rise of B2M concentrations are progressive with the severity of the
       disease. The Cu concentrations were within the normal range in 84% of
       cases. Moreover, significant negative correlations were observed
       between: B2M and CD4/CD8 ratio, B2M and CD4 expressed in %, B2M and Zn
       values, B2M and Se values. There was also a negative relation between Se
       and Zn concentrations. No relationship between all the different
       parameters was found in control group. According to the clinical
       evolution in the 2 ensuing years, similar observations were found one
       year later in survival patients where as no correlation was observed in
       subjects who died in the following 12 months (24 and 10 subjects died
       respectively in the next 12 and 24 months). CONCLUSION: HIV patients
       exhibited relationship between specific and nonspecific markers of
       immune system activity and trace element status which are not observed
       in HIV seronegative subjects. These correlations seems to reflect the
       immune dysregulation as well as an increased oxydative stress and an
       accelerated HIV replication. By resulting from a total immune
       derangement associated with opportunistic infections and/or
       gastrointestinal diseases, the lack of all the correlations between the
       different parameters in patients with survival < 1 year argues for a
       increased risk factor of unfavorable evolution.
 DE    beta 2-Microglobulin/METABOLISM  Adult  Biological Markers/*BLOOD
       Copper/BLOOD  CD4-CD8 Ratio  Female  Follow-Up Studies  Human  HIV
       Infections/CLASSIFICATION/*DIAGNOSIS/IMMUNOLOGY  Male  Middle Age
       Selenium/BLOOD  Trace Elements/*BLOOD  Zinc/BLOOD  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).